Clinical Review of Thalassemia: Kinds, Signs Management, and Globin Structure

Authors

  • Mustafa Hamoodi Jabbar University of AL- Qadisiyah AL Diwanyia Iraq
  • Nasreen Rahman Mohammed University of AL- Qadisiyah AL Diwanyia Iraq
  • Fadhaa Jaber Shinjar University of AL- Qadisiyah AL Diwanyia Iraq
  • Heba Suhail kadhem University of AL- Qadisiyah AL Diwanyia Iraq
  • Zainab Abd Ali Salman University of AL- Qadisiyah AL Diwanyia Iraq

Keywords:

Thalassemia, hemoglobin, Anemia, Alpha thalassemia

Abstract

Thalassemia is a blood disease in which the typical hemoglobin is synthesized in minor quantities than normal. It is genetic disease consequently it passed from parents via their genes. Thalassemia patients cannot synthesize sufficient typical hemoglobin, that causes serious anemia. Hemoglobin is present in erythrocytes and transports O2 to all organs of the body. Around the world, there are approximately 30 million carriers in addition to about 10000 babies have thalassemia annually. In fact, two main types of thalassemia are found. These types are Alpha thalassemia which affected by Alpha globin gene and Beta Thalassemia which affected by Beta globin gene. In this review we focus on thalassemia disorder, kinds and its management.

References

Galanello R, Origa R: Beta-thalassemia. Orphanet J Rare Dis. 2010, 5:11-18. 10.1186/1750- 1172-5-11

Shirzadfar H, Mokhtari N, Claudel J (2018) geometric parameters optimization of interdigital micro-electrodes: theoretical analysis. Accepted by Journal of Nano and Electronic Physics

Ameli M, Besharati S, Nemati K, Zamani F: Relationship between elevated liver enzyme with iron overload and viral hepatitis in thalassemia major patients in Northern Iran. Saudi Med J. 2008, 29:1611-1615.

Sharada AS: Thalassemia and related hemoglobinopathies. Ind J Pediatr. 2005, 72:319-324. 10.1007/BF02724015

Brittenham, GM, Patricia GM, Arthur NW, Christine ME, Young NS, et al. (1994) Efficacy of deferoxamine in preventing complications of iron overload in patients with thalassemia major. New England Journal of Medicine 331(9): 567–573

Akhavan H, Derakhshandeh P, Banihashemi A, Mostafazadeh A, Asghari B, Ahmadifard MR, Azizi M, Youssefi A, Elmi MM. A comprehensive molecular characterization of beta thalassemia in a highly heterogeneous population. Blood Cells Mol Dis.2011; 15;47(1):29-32

Martin A, Thompson AA. Thalassemias. Pediatr Clin North Am.2013; 60:1383.

Hemoglobin-alpha locus 1 HBA2. Online mendelian inheritance in man (OMIM) 141850

Hemoglobin-alpha locus 1 HBA2. Online mendelian inheritance in man (OMIM) 141850.

Lukens JN (1993) The thalassemias and related disorders: quantitative disorders of hemoglobin synthesis. Bayl Univ Med Cent 20(1): 27-31

Nigam N, Nigam S, Agarwal M, Singh PK (2015) β-Thalassemia: From clinical symptoms to the management IJCMR 4(5): 1-5.

Papanikolaou G, Tzilianos M, Christakis JI, et al.: Hepcidin in iron overload disorders. Blood. 2005, 105:4103-4105. 10.1182/blood-2004-12-4844.

Vincenzo D, Christos K. β-Thalassemia Distribution in the Old World: an Ancient Disease Seen from a Historical Standpoint” (2017); 9(1): e2017018

NA Al-Allawi, K Hassan. βthalassemia mutations among transfusion dependent thalassemia major patients in Northern Iraq,” Molecular Biology International. 2010; 4.

Makis A, Hatzimichael E, Papassotiriou I, Voskaridou E: 2017 clinical trials update in new treatments of β‐thalassemia. Am J Hematol. 2016, 91:1135-1145. 10.1002/ajh.24530.

Samavat A, Modell B (2004) Iranian national thalassaemia screening programme. BMJ 329(7475): 1134–1137

Aisen P, Leibman A, Zweier J, Zweier L (1978) Stoichiometric and site characteristics of the binding of iron to human transferrin. J Biol Chem 253(6): 1930–1937.

Thalassemia International Federation: Guidelines for the clinical management of thalassemia (2nd edn).

Maton A, Hopkins, McLaughlin GW, Johnson S, Warner MQ, et al. (1993) Human biology and health. Englewood Cliffs, New Jersey, USA.

Steensma DP, Gibbons RJ, Higgs DR (2005) Acquired α-thalassemia in association with myelodysplastic syndrome and other hematologic malignancies. Blood 105(2): 443-452.

Lehmann H, Carrell RW (1968) Differences between alpha and beta chain mutants of human haemoglobin and between alpha and beta thalassaemia, Possible duplication of the alpha chain gene. Br Med J 4(5633): 748–750

Downloads

Published

2023-09-07

How to Cite

Mustafa Hamoodi Jabbar, Nasreen Rahman Mohammed, Fadhaa Jaber Shinjar, Heba Suhail kadhem, & Zainab Abd Ali Salman. (2023). Clinical Review of Thalassemia: Kinds, Signs Management, and Globin Structure. Czech Journal of Multidisciplinary Innovations, 21, 1–5. Retrieved from https://peerianjournal.com/index.php/czjmi/article/view/627

Issue

Vol. 21 (2023): CZJMI

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

You are free to:

  1. Share — copy and redistribute the material in any medium or format
  2. Adapt — remix, transform, and build upon the material
  3. The licensor cannot revoke these freedoms as long as you follow the license terms.

Under the following terms:

  1. Attribution — You must give appropriate credit , provide a link to the license, and indicate if changes were made . You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
  2. NonCommercial — You may not use the material for commercial purposes .
  3. No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits

Most read articles by the same author(s)