The Immune System as An Important Participant In The Development of Atherosclerosis (Review)
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Abstract
The significant inclusiveness of the activity of the immune system in the extremely diverse mechanisms of the occurrence and development of atherosclerosis does not raise any doubts today. A modern review of literature sources on the participation of the human immune system in the pathogenesis of atherosclerosis seems relevant. Along with the latest data, information is also presented on classical fundamental theories that reveal numerous aspects of the problem under study. Conclusions include the statement that the immune system and immunopathological processes play a huge role in the pathogenesis of atherosclerosis.
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References
Don A.N. Morphofunctional state of the pituitary gland and thyroid gland under the influence of ladyginoside and its aglycone hederagenin: Ph.D. dis. - Tashkent. 1994.-20s, 1994. (Russ.) Дон А. Н. Морфофункциональное состояние гипофиза и щитовидной железы под влиянием ладыгинозида и его агликона хедерагенина: канд. дис. – Ташкент. 1994.-20с, 1994.
Don, A. N., & Nagai, S. G. (2022). Experimental study of the administration of dipsacoside to the structure of the thyroid gland. MedUnion, (1), 19-24. (Russ.) Дон, А. Н., & Нагай, С. Г. (2022). Изучение введения дипсакозида на структуру щитовидной железы в эксперименте. MedUnion, (1), 19-24.
Novikova E. O. et al. PHARMACOTHERAPY OF PATIENTS WITH ATHEROSCLEROSIS // Published by decision of the editorial and publishing council of the FSBEI HE KSMU of the Ministry of Health of Russia. – 2023. – P. 248.
Don A.N., Kakharov Z.A., Khvan O.I. The effectiveness of experimental herbal medicine for atherosclerosis with saponins // Scientific and practical journal “Re-health journal”. – 2024. - No. 1.- P. 1 – 6. (Russ.) Дон А.Н., Кахаров З.А., Хван О.И. Эффективность экспериментальной фитотерапии атеросклероза сапонинами // Научно-практический журнал «Re-health journal». – 2024. - № 1.- С. 1 – 6.
Don, S. Usanova, S. Safarova, and S. Nagai. On the issue of prevention and treatment of atherosclerosis with herbal preparations // Preventive medicine and health. - 2022 - vol. 1. - No. 1. - pp. 1-8. (Russ.) А. Дон, С. Усанова, С. Сафарова, и С. Нагай. К вопросу профилактики и лечения атеросклероза растительными препаратами // Профилактическая медицина и здоровье. - 2022 г. - т. 1. - № 1. - С. 1-8. https://inscience.uz/index.php/preventive-medicine/article/view/2400 .
Don AN, Nishanova AA Coherence of the development of atherosclerosis and ethnic food traditions of the world. Review // Web of Scientist: International Scientific Research Journal ( WoS ), Volume 5, Issue 01, January, 2024, p. 28-39. ISSN: 2776-0979.
Latfullin I. A. et al. DIAGNOSTICS OF TAKO-TSUBO SYNDROME IN FORENSIC PRACTICE (literature review) // CURRENT ISSUES OF FORENSIC MEDICINE AND LAW. – 2022. – P. 70-101.
Kiseleva D. G. et al. PRO-ATHEROGENIC PROTEOMIC PROFILE OF LDL OBTAINED FROM PATIENTS WITH DIABETES MELLITUS: IMMUNOLOGICAL ASPECTS // Russian Immunological Journal. – 2024.
Tuguz A. R. et al. Imbalance of NK cell subpopulations and polymorphisms of anti-inflammatory cytokine genes in the pathogenesis of atherosclerosis // Medical Immunology. – 2022. – T. 24. – No. 1. – pp. 135-146.
Don AN, Artykov DD, & Gulomov SS (2023). Review of multimorbid conditions in atherosclerosis. Journal of New Century Innovations , 42(1), 156–162.
Don A. N., Kakharov Z. A., Nazirjonov O. Kh. U. Modern aspects of comorbidity of atherosclerosis. Review. // Life Sciences and Agriculture. – 2022. – No. 3 (11). – pp. 29-37. (Russ.) Дон А. Н., Кахаров З. А., Назиржонов О. Х. У. Современные аспекты коморбидности атеросклероза. Обзор. // Life Sciences and Agriculture. – 2022. – №. 3 (11). – С. 29-37.
Don A.N. On the issue of the importance of a healthy lifestyle in the prevention of atherosclerosis // Central Asian Journal of Endocrinology. - 2022. - No. 2. – p. 56 – 60. (Russ.) Дон А.Н. К вопросу о значении здорового образа жизни в профилактике атеросклероза // Центрально Азиатский эндокринологический журнал. - 2022. - № 2. – с. 56 – 60. http://dx.doi.org/10.5281/zenodo.7463513 .
Don A.N., Kakhkharov Z.A., Artykov D.D. Atherosclerosis: a socio-economic challenge of our time and ways to improve public health //Re-health journal. – 2022. – No. 3 (15). – pp. 31-33. (Russ.) Дон А. Н., Каххаров З. А., Артыков Д. Д. Атеросклероз: социально-экономический вызов современности и пути улучшения общественного здравоохранения //Re-health journal. – 2022. – №. 3 (15). – С. 31-33.
Don A. N., Reimnazarova G. D., Nishanova A. A. Health promotion and socio-economic aspects of atherosclerosis // Academic research in educational sciences . – 2022. – No. 2. – pp. 107-111. (Russ.) Дон А. Н., Реймназарова Г. Д., Нишанова А. А. Содействие укреплению здоровья и социально-экономические аспекты атеросклероза //Academic research in educational sciences. – 2022. – №. 2. – С. 107-111.
Sapozhnikov S.A. Assessing the prevalence of cardiovascular disease risk factors among medical students. Atherosclerosis. 2023;19(3):232-233. https://doi.org/10.52727/2078-256X-2023-19-3-232-233 .
Don A.N., Nurov A.R., Ashirmatov Sh.N. Immunological aspects of atherosclerosis: a review // “Journal of Theoretical and Clinical Medicine”, 2022, No. 4, pp. 34 – 35. (Russ.) Дон А.Н., Нуров А.Р., Аширматов Ш.Н. Иммунологические аспекты атеросклероза: обзор // «Журнал теоретической и клинической медицины», 2022, № 4, С. 34 – 35.
Latfullin I.A. Atherosclerosis (brief history of development, causes, pathogenesis of the disease, risk factors, principles of prevention) // I.A. Latfullin. – Kazan: Kazan Publishing House. Univ., 2015. – 144 p.
Shcheglov D.S. The relationship between immunological disorders and multifocal atherosclerosis in patients with stable angina. – Diss ... candidate of medical sciences . - Saint Petersburg. – 2018. – p. 142.
Yuryeva E.A., Sukhorukov V.S., Vozdvizhenskaya E.S. and others. Atherosclerosis - hypotheses and theories // Russian Bulletin of Perinatology and Pediatrics. - No. 3. – 2014. P. 6 – 16.
Don, A. N., & Nagai, S. G. (2022). Experimental study of the administration of dipsacoside to the structure of the thyroid gland. MedUnion, (1), 19-24.
Nishanova AA, Don AN, Sharipova PA, Reimnazarova GD Structural metamorphosis of thyroid status initiated by saponin introduction. Scientific aspects and trends in the field of scientific research: a collection of scientific works of the International scientific online conference (30th October, 2022) – Poland, Warsaw: “CESS”, 2022. Part 3– P. 139 – 143.
Don A. N., Nagai S. G. Thyroid gland: point test method of morphometric analysis in experimental atherosclerosis // Leg . Med . – 2017. – T. 26. – P. 45-51. (Russ.) Дон А. Н., Нагай С. Г. Щитовидная железа: тест-точковый метод морфометрического анализа при экспериментальном атеросклерозе //Leg. Med. – 2017. – Т. 26. – С. 45-51.
Sadykova D.Z., Don A.N., Mamataliev A.R. Changes in the adrenal glands in hypercholesterolemia under the influence of dipsacoside. – Innovations in medicine and pharmacy 2022: collection of materials from the International Scientific and Practical Conference of Students and Young Scientists / ed. S.P. Rubnikovich , V.A. Filonyuk . – Minsk: BSMU. – 03/18/2023. – pp. 927 – 929. (Russ.) Садыкова Д. З., Дон А. Н., Маматалиев А. Р. Изменение надпочечников при гиперхолестеринемии под влиянием дипсакозида. – Инновации в медицине и фармации 2022: сборник материалов Международной научно-практической конференции студентов и молодых ученых / под ред. С.П. Рубниковича, В.А. Филонюка. – Минск: БГМУ. – 18.03.2023. – С. 927 – 929.
Ablakimov N.K., Don A.N., Mamatalieva M.A. Changes in the adrenal glands in hypercholesterolemia under the influence of dipsacoside // World Science. – 2023. – No. 2 (71). – pp. 42-45. (Russ.) Аблакимов Н. K., Дон А. Н., Маматалиева М. А. Изменение надпочечников при гиперхолестеринемии под влиянием дипсакозида //Мировая наука. – 2023. – №. 2 (71). – С. 42-45.
Mamataliev A. R. , Shaguyamova K.L., Usanova S.T. , 23. NA Miz and akhmedova N.A. , Don AN Adrenal morphology in hypercholesterolemia under the influence of Dipsacosid // International scientific journal "Educational News: Research in the 21st Century". - 2022 y. - No. 5 (100), v. 1. – p. 1062 – 1066.
N K Ablakimov , AN Don, AR Mamataliev. Karyometric indicators of different zones of the adrenal glands in experimental hypercholesterolemia under the influence of dipsacoside // IQRO 2 (1). 156-160. (Russ.) НK Аблакимов, АН Дон, АР Маматалиев. Кариометрические показатели различных зон надпочечников при экспериментальной гиперхолестеринемии под влиянием дипсакозида // IQRO 2 (1). 156-160.
Don, A., & Azizov, Y. (2022). Features of the morphology of the pituitary gland during the experimental administration of hederagenin. in Library, 22(1), 175-182. (Russ.) Дон, А., & Азизов, Ю. (2022). Особенности морфологии гипофиза при экспериментальном введении хедерагенина. in Library, 22(1), 175-182.
Don AN Morphofunctional state of the pituitary gland and thyroid gland under the influence of ladyginoside and its aglycone hederagenin: dis. – Tashkent. 1994.-20c, 1994.
Don. Alteration – as a section of pathological anatomy [Text]: Educational manual / A. Don. – Tashkent. - Publishing house “Complex Print”. – 2023. – 136 p.
Dzhumabaev S.U., Don A.N. Lymph node and its clinical significance // Journal of Lymphology. - No. 1. - 1995 - Andijan. NPK "Lymfa" - p.38-44. (Russ.) Джумабаев С.У., Дон А.Н. Лимфатический узел и его клиническое значение // Журнал Лимфология. - №1. - 1995 г. - Андижан. НПК «Лимфа». - с.38-44.
Parshina A. A., Tsybikov N. N. Immunological aspects of the pathogenesis of atherosclerosis // Transbaikal Medical Bulletin. – 2018. – No. 4. – pp. 133-144.
Mamataliev A., Don A. Effect of dipsacoside on the liver and aorta in experimental hypercholesterolemia // in Library . – 2022. – T. 22. – No. 1. – pp. 163-165. (Russ.) Маматалиев А., Дон А. Влияние дипсакозида на печень и аорту при экспериментальной гиперхолестеринемии // in Library. – 2022. – Т. 22. – №. 1. – С. 163-165.
Klimchuk A. V. et al. Atherosclerosis: immunological aspects of pathogenesis, the role of inflammation, therapeutic strategies, prospects for the use of nanotechnologies // Tauride Medical and Biological Bulletin. – 2021. – T. 24. – No. 3. – pp. 77-89.
Kozlov V. A. Suppressor cells are the basis of the immunopathogenesis of atherosclerosis // Atherosclerosis. – 2022. – T. 11. – No. 2. – pp. 37-42.
Talibova D. et al. The role of oral microflora in the development of atherosclerosis and other diseases // Scientific Collection " InterConf ". – 2024. – No. 188. – pp. 311-315.
Zwinger S. M. et al. The level of some cytokines and the incidence of atherosclerosis in patients with osteoarthritis, depending on the severity of algofunctional disorders in the joints // Far Eastern Medical Journal. – 2020. – No. 4. – pp. 21-25.
Khalikova U. Akhmadalieva U. K. Immunological changes in certain diseases of the cardiovascular system // Research Archive. – 2020. – pp. 13-13.
Kozik V. A. et al. Assessment of the association of the rs12329760 polymorphism of the TMPRSS2 gene with acute coronary syndrome in patients who have suffered a new coronavirus infection // Atherosclerosis. – 2024. – T. 20. – No. 1. – pp. 35-41.
Obukhovich, A. R., Ioskevich , N. N., Vasilevsky, V. P., & Dainovich , V. A. (2024). The role of folate cycle gene polymorphism in the development of atherosclerosis and type 2 diabetes mellitus.
Dolgushin I. I. et al. Relationships between immunosuppressive neutrophils and indicators of innate and adaptive immunity in patients with subclinical atherosclerosis // Medical Immunology. – 2022. – T. 24. – No. 2. – pp. 283-294.
Prudnikov A. R., Shchupakova A. N. The role of cytokines in the diagnosis of instability of atherosclerotic plaque // Bulletin of Vitebsk State Medical University. – 2018. – T. 17. – No. 5. – pp. 28-42.
Snigirev AY, Terentiev a OS, Shklyaeva NP ANTIBODIES TO GP120 HIV-1 IN AN EXPERIMENTAL MODEL OF ATHEROSCLEROSIS CAUSED BY IMMUNIZATION WITH NATIVE HIGH-DENSITY LIPOPROTEINS //Russian Journal of Immunology. – 2024.
Kirichenko T.V. et al. INFLUENCE OF STATIN TAKEN ON THE INFLAMMATORY RESPONSE OF MONOCYTES IN PATIENTS WITH ATHEROSCLEROSIS //Russian Immunological Journal. – 2024.
Kologrivova I.V. et al. LYMPHOCYTE SUBPOPULATS IN EPICARDIAL, THYMUS AND SUBCUTANIUM ADIPOSE TISSUE WITH STRONG CORONARY ATHEROSCLEROSIS IN PATIENTS WITH CORONARY HEART DISEASE //Russian Immunological Journal. – 2024.
Smirnova N. N., Kuprienko N. B., Urazgildeeva S. A. Function of high-density lipoproteins in various pathological conditions // Scientific notes of the First St. Petersburg State Medical University named after Academician IP Pavlov. – 2024. – T. 30. – No. 3. – pp. 16-21.
Klimov A.N., Nagornev V.A., Denisenko A.D., Konstantinov V.O. Autoimmune theory of the pathogenesis of atherosclerosis and new ways of its treatment // Vestn . RAMS, 2003. -No. 12. – S. -29 – 34.
Nagornev V.A., Anestiadi V.Kh., Zota E.G. Pathomorphosis of atherosclerosis ( immunoaspects ). St. Petersburg - Chisinau, 2008. - 320 pp.
Boeva E. V. et al. The nature and essence of immunosuppressive conditions //HIV infection and immunosuppression. – 2024. – T. 15. – No. 4. – P. 7-24.
Kologrivova I. et al. LYMPHOCYTE SUBSETS IN EPICARDIAL, THYMIC AND SUBCUTANEOUS ADIPOSE TISSUE DURING ADVANCED CORONARY ATHEROSCLEROSIS IN PATIENTS WITH CORONARY ARTERY DISEASE //Russian Journal of Immunology. – 2024.
Kiseleva, D. G., Ziganshin, R. Kh., Fotin, D. P., & Markin, A. M. (2024). Proterogenic proteomic profile of LDL obtained from patients with diabetes mellitus: immunological aspects // Russian Immunological Journal.
Kologrivova I.V. et al. Relationship between the content of FoxP3+ T-regulatory lymphocytes and the thickness of epicardial adipose tissue in patients with coronary heart disease // Acta Biomedica scientifica . – 2024. – T. 9. – No. 1. – pp. 42-52.